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腳踝扭傷可能是缺少透明質酸 (HA)

已有 914 次閱讀2022-12-31 06:25 AM

落枕應該是頸部缺少透明質酸(玻尿酸)，和漸凍人的關聯性。

http://www.eyny.com/blog-5788411-789162.html

告訴我們：

玻尿酸（英語：Hyaluronan、Hyaluronic acid），又稱透明質酸

節錄自https://zh.wikipedia.org/zh-tw/玻尿酸

IL-1β–induced hyaluronic acid synthase (HAS) expression

IL-1β 誘導的透明質酸合成酶 (HAS) 表達

節錄自https://iovs.arvojournals.org/article.aspx?articleid=2189818

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小胖威利症治療總整理(建議善存+維他命C、B6+多喝豆漿、一天吃2~3大根香蕉)

http://www.eyny.com/blog-5788411-777695.html

告訴我們：

IFN-γ治療後IL-1β蛋白表達增加。

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hyaluronan (HA)

透明質酸 (HA)

IL-10 mediated HA synthesis is essential for the fetal fibroblasts' enhanced invasion and migration properties.

IL-10 介導的 HA 合成對於胎兒成纖維細胞增強的侵襲和遷移特性至關重要。

節錄自https://pubmed.ncbi.nlm.nih.gov/25951109/

Additional periarticular injection of hyaluronic acid for the treatment of acute ankle sprains leads to a significant faster pain relief
額外的關節周圍注射透明質酸用於治療急性踝關節扭傷導致顯著更快的疼痛緩解
節錄自https://www.semanticscholar.org/paper/Influence-of-Hyaluronic-Acid-on-the-Clinical-Course-Jakobs-Wirbel/4a7e8c5c24fc968c97305bdc5dd9648872d5543c

osteoarthritis (OA)
骨關節炎 (OA)
hyaluronic acid (HA)
透明質酸 (HA)
Intra-articular HA administration can significantly reduce pain in ankle OA compared with the condition before treatment
與治療前相比，關節內註射 HA 可顯著減輕踝關節 OA 的疼痛
節錄自https://pubmed.ncbi.nlm.nih.gov/23149311/

Hyaluronic acid is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded via ABC-Transporter[7] into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints
透明質酸由質膜內表面的膜結合合酶合成，鏈通過ABC-轉運體[7]被擠出到細胞外空間。它具有多種功能，包括空間填充、關節潤滑
節錄自https://en.wikipedia.org/wiki/HAS2

The ankle is composed of three joints: the talocrural joint (also called talotibial joint, tibiotalar joint, talar mortise, talar joint), the subtalar joint (also called talocalcaneal), and the Inferior tibiofibular joint.
踝關節由三個關節組成：距小腿關節（也稱為距脛關節、脛距關節、距臼、距骨關節）、距下關節（也稱為距跟關節）和下脛腓關節。
節錄自https://en.wikipedia.org/wiki/Ankle

【透明質酸由質膜內表面的膜結合合酶合成，它具有多種功能，包括空間填充、關節潤滑】+【踝關節由三個關節組成】
代表踝關節周遭應該有透明質酸合成酶 (HAS)

Synovial tissues were collected postmortem from normal joints.
從正常關節死後收集滑膜組織。
節錄自https://ashpublications.org/blood/article/111/5/2631/109938/Specific-plasma-membrane-protein-phenotype-of
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Synovial membranes line the inner surface of the capsule of a synovial joint and contain synovial fluid within; which functions to lubricate joint movement.
滑膜排列在滑膜關節囊的內表面，內部含有滑液；起到潤滑關節運動的作用。
節錄自https://med.libretexts.org/Bookshelves/Anatomy_and_Physiology/Book%3A_Anatomy_and_Physiology_(Boundless)/4%3A_Organization_at_the_Tissue_Level/4.6%3A_Tissue_Membranes/4.6B%3A_Synovial_Membranes
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Normally, synovial fluid contains high levels of hyaluronic acid (HA) that help to maintain high fluid viscosity and the normal integrity of the joint by attenuating inflammation and preserving the normal cartilaginous matrix.
通常，滑液含有高水平的透明質酸 (HA)，有助於通過減輕炎症和保護正常的軟骨基質來維持高流體粘度和關節的正常完整性。
節錄自https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788189/

所以關節有滑膜組織→滑膜含有滑液→滑液含有高水平的透明質酸 (HA)→可能滑膜組織就是上述的【透明質酸由質膜內表面的膜結合合酶合成】的質膜plasma membrane